ConceptGen: a gene set enrichment and gene set relation mapping tool
نویسندگان
چکیده
منابع مشابه
ConceptGen: a gene set enrichment and gene set relation mapping tool
MOTIVATION The elucidation of biological concepts enriched with differentially expressed genes has become an integral part of the analysis and interpretation of genomic data. Of additional importance is the ability to explore networks of relationships among previously defined biological concepts from diverse information sources, and to explore results visually from multiple perspectives. Accomp...
متن کاملConceptGen: A gene set enrichment and gene set relation mapping tool Concept Building
Gene Ontology, KEGG pathway, Biocarta Pathway, Panther Pathway, and Pfam information were downloaded from their respective sources. For Pfam, Uniprot IDs were mapped to Entrez Gene IDs, thus resulting in all transcripts for a gene being mapped to the same Pfam terms. Chromosomal location was determined by NCBI cytoband assignment, and gene expression signatures were defined as detailed below. T...
متن کاملExtensions to gene set enrichment
MOTIVATION Gene Set Enrichment Analysis (GSEA) has been developed recently to capture changes in the expression of pre-defined sets of genes. We propose number of extensions to GSEA, including the use of different statistics to describe the association between genes and phenotypes of interest. We make use of dimension reduction procedures, such as principle component analysis, to identify gene ...
متن کاملGene set enrichment; a problem of pathways.
Gene Set Enrichment (GSE) is a computational technique which determines whether a priori defined set of genes show statistically significant differential expression between two phenotypes. Currently, the gene sets used for GSE are derived from annotation or pathway databases, which often contain computationally based and unrepresentative data. Here, we propose a novel approach for the generatio...
متن کاملA RELATION BETWEEN THE CATEGORIES Set * , SetT, Set AND SetT
In this article, we have shown, for the add-point monad T, thepartial morphism category Set*is isomorphic to the Kleisli category SetT. Alsowe have proved that the category, SetT, of T-algebras is isomorphic to thecategory Set of pointed sets. Finally we have established commutative squaresinvolving these categories.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2009
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btp683